Category: Diabetes Numbers

Diabetes Mellitus Type 1

The medical community contributes the name diabetes mellitus (or diabetes) to a group of disorders where the body cannot regulate its blood sugar, or blood glucose, levels. There are two main types of diabetes: type 1 and type 2.


Diabetes Mellitus


Type 1 diabetes which is also called insulin-dependent diabetes or juvenile diabetes, involves immune system disorders of the body. Our immune system protects us from bacteria, viruses, or other materials. Type 1 diabetes diagnosed in age 30+ adults may be LADA (or Latent Autoimmune Diabetes in Adults). This is also called type 1.5 diabetes. Because of the age at which it first occurs, LADA is often incorrectly thought to be type 2 diabetes. However, with LADA, people are not insulin resistant like a person with type 2 diabetes. The characteristics of LADA are: age of onset, no known family history of type 2, positive antibodies, gradual increases in insulin demands, and lessened ability to make insulin which is indicated when the person has a low C-peptide. A fourth, rare diabetes strikes newborns,(monogenic) but is typically mistaken for type 1 diabetes.

English: idealized curves of human blood gluco...

English: idealized curves of human blood glucose and insulin concentrations during the course of a day containing three meals; in addition, effect of sugar-rich meal is highlighted. (Photo credit: Wikipedia)


Type One Diabetes


Type 1 diabetes happens when your body’s immune system suppresses specific cells in your pancreas. The pancreas is about as big as your hand and found behind the lower portion of your abdomen. These beta cells are held, along with others, within tiny islands known as pancreatic islets. Beta cells typically make insulin, which is a hormone that helps your body propel the glucose in your food into cells throughout your body which consumes it as energy. When these beta cells are attacked and destroyed, no insulin can be made and glucose remains in your blood, causing severe damage within your body’s organs.


Because of this, if you have type 1 diabetes, you must take insulin to live. This means numerous injections everyday or the use of an insulin pump, and also numerous blood sugar tests by finger pricks 6 or more times daily.  People who are diabetic must also maintain a balance between what they eat and exercise to adjust their blood sugar level to avoid either low blood sugar (hypoglycemic) or high blood sugar (hyperglycemic) conditions that can be deadly.


Warning Signs of Type 1


Warning signs of type 1 diabetes include frequent urination, excessive thirst, sugar in urine, lethargy or sleepiness, a bigger appetite, weight loss that occurs suddenly, fruity or sweet smell on your breath,sudden changes in your vision, heavy breathing, loss of consciousness, and dulled senses.

Type 1 diabetes is typically found in young children all the way through young adulthood. Scientist do not know the precise cause of this disease, but they do believe that genetic, environmental, and autoimmune elements make up a part of the disease’s process.






Is Type 1 Diabetes Cure The Next Big Development?

In June 2012, a new study introduced the world to a real possibility of a type 1 diabetes cure. For Type 1 diabetics and the people who love them, this news has important implications about their health and their future. Although trials are still in their beginning stages, preliminary discoveries suggest that this new avenue of treatment has the potential to cure Type 1 diabetes once and for all.

Type 1 Diabetes Cure

Type 1 Diabetes Symptoms

Type 1 diabetes is an autoimmune disorder. A difference in a type 1 diabetic’s genes causes the body’s T cells to attack its own insulin-producing beta cells. Without these cells, the body can’t produce insulin. Without this insulin, type 1 diabetics cannot control their blood sugar levels.

Consequently, type 1 diabetics are dependent on insulin supplements. It was once thought that Type 1 diabetics were doomed to be insulin dependent for their entire lives. Once the body’s insulin-producing beta cells were destroyed, scientists thought, they could not be regenerated. But this new type 1 diabetes
cure research from Baylor College of Medicine in Houston turns most of traditional understanding of Type 1 diabetes on its head.

Type 1 Diabetes Cure Research


In the search for a type 1 diabetes cure, June 2011 was an important date that marked the potential discovery of a permanent solution. The key to the new diabetes cure is a two-part attack. One part stimulates the body to produce new insulin-producing beta cells. This new cell generation is stimulated by neutrogenin3, a gene they introduce into the body via an injection. Once in the body, the gene stimulates the formation and continual production of new cells.

The other part of this potential type 1 diabetes cure’s one-two punch protects those newly formed beta cells. Scientists accomplish this with another feat of genetic engineering. This time the savior is a gene called CD274. This gene incapacitates any T cells that come near the beta cells in the liver. And because it specializes, the gene does not attack any healthy cells anywhere else in the body.

This combination of cell regeneration and protection is promising. With gene therapy, doctors can help the body do what it naturally cannot. And because it introduces these changes without harmful chemicals, patients do not run the risk of toxic side effects.

Type 1 Diabetes Treatment


Scientists first tested their new gene therapy on mice. The subjects were 22 non-obese mice suffering from type 1 diabetes. Each of the mice were given one injection of the gene therapy.

After one injection of this potential type 1 diabetes cure, the changes were dramatic. 17 out of 22 of the mice — around 80 percent — had normal insulin levels return. Their type 1 diabetes — previously thought to be incurable — had reversed. Their blood sugar and insulin levels returned to normal as if they had never had the disorder.

Type 1 Diabetes Cure

These mice not only enjoyed healthier lives; they were longer two. Mice with type 1 diabetes usually only live six to eight weeks. However, with this new potential type 1 diabetes cure, type 1 diabetes life expectancy has the potential to increase significantly. Mice with reversed type 1 diabetes lived as long as 18 weeks after they received the injection.

The 5 mice that were not completely cured became diabetic again after a short period of respite. These outlying mice are opening up other avenues of study for the scientists. They are experimenting with the dosage of genes and the type of genes used. Once they get the formula right, human trials are expected to begin.

For type 1 diabetics and the people who love them, it is difficult to imagine more exciting news. In the fight for a type 1 diabetes cure, 2011was a banner year. These new studies have the potential to reduce the pernicious effects of type 1 diabetes, a disease that affects millions around the world. For those hoping for a type 1 diabetes cure, these trials show the most promise.



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Type 3 Diabetes Attacks Your Brain?


Most of us have heard about type 1 or type 2 diabetes, but Type 3 diabetes barely puts a blip on the radar. Although discovered in 2005, this new condition is just beginning to pop up on the headlines of today’s science and medical news journals. Lay people still have a lot to learn.

When it comes to type 3 diabetes, Wikipedia doesn’t even have the answers. The relatively new discovery of the disease leaves people concerned about their health searching for answers. Read on for a quick primer on diabetes mellitus 3 and how it may be affecting your health or the health of your loved ones.

Type 3 Diabetes: What is it?

During a study conducted at the Rhode Island Hospital and Brown Medical School, researchers made a groundbreaking discovery: the hormone insulin was not just produced by the pancreas as previously thought. After careful study of their Type 3 Diabetessubjects, the researchers discovered that the brain was also responsible to producing small amounts of insulin. This discovery led to several more important revelations.

One of those revelations was the discovery of insulin’s effect on the brain. One of those effects on the brain is the development of diabetes mellitus 3. Type 3 diabetes is a condition where the brain does not produce enough insulin. In the absence of insulin, the brain is affected much the way the body is in type 1 or type 2 diabetes. In fact, diabetes mellitus 3 only occurs in people who have either type 1 or type 2 diabetes already.

Type 3 Diabetes: Alzheimer’s in Disguise

Diabetes mellitus 3 is also known as brain diabetes. This is because the brain requires insulin to form new memories. Receptors on the brain’s synapses help facilitate the communication that creates new memories. The insulin produced by the brain wards off amyloid beta-derived diffusible ligands (ADDLs)that destroy those receptors.

In diabetes mellitus 3, the brain is either doesn’t produce enough insulin for new memory formation or is resistant to the insulin it produces. Without insulin, those insulin receptors die. Without those insulin receptors, the brain can’t form new memories.

This inability to form new memories is what produces the type 3 diabetes symptoms, signs and difficulties that mimic those of Alzheimer’s and dementia. Sufferers experience the memory loss and confusion that is typical of both diseases. Because of the similarity of these diseases, doctors often have trouble diagnosing diabetes mellitus 3 unless they are specifically looking for it using Magnetic Resonance Imaging (MRI) scanning technology.

Type 3 Diabetes: Treatment

Diabetes mellitus 3 was only officially recognized as an illness in 2005. But doctors already know quite a bit about how to treat the disease. Much of that head start is thanks to the fact that the treatment for type 3 diabetes symptoms is very similar to the treatment for diabetes mellitus 2.

One of the keys to treating and preventing the onset of diabetes mellitus 3 is to exercise. Regular exercise three to five times a week combined with a healthy diet helps to maintain the healthy weight that wards off the disease. Obesity — especially in women — is a key factor in the onset of both type 2 and type 3 diabetes.

Doctors also treat diabetes mellitus 3 with the same drugs used to treat type 2 diabetes like regular doses of insulin and insulin-sensitizing rosiglitazone. These drugs actually slow and even prevent further memory loss. They do this by protecting the brain’s neurons from the damaging ADDLs.

Cholesterol build up is another similarity between diabetes of all types and Alzheimers. Certain preliminary trials have found that lipid lowering drugs used to fight high cholesterol are effective in treating diabetes mellitus 3. Today, many type 3 diabetes sufferers are turning to this drug for relief.

Diabetes mellitus 3 is a newly-discovered disease that leaves many questions still to be answered. But as we discover more about all types of diabetes, treatments are improving. If you or someone you know is suffering from the symptoms of type 3 diabetes, Mayo Clinic and Wikipedia searches aren’t enough. Contact your doctor as soon as possible to catch and treat type 3 diabetes in its primary stage.


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